Aniston & Mayer Call It Quits?

E! is reporting that Jennifer Aniston and John Mayer have broken up again.

A source says that the pair's on-again, off-again relationship may have ended when Aniston returned from overseas, where she was promoting Marley & Me. She returned sometime within the last week.

"He broke up with her when she got back from her European tour," the source said.

Aniston's rep did not immediately comment. Mayer's rep declined to comment on the singer's personal life.

Note, once again, HE broke up with HER. I'm sure he'll hold an impromptu press conference to make sure we know that again. He must be DYING to chat with the paps! It's been too long!